Copper-catalyzed diastereoselective arylation of tryptophan derivatives: total synthesis of (+)-naseseazines A and B.
نویسندگان
چکیده
A copper-catalyzed arylation of tryptophan derivatives is reported. The reaction proceeds with high site- and diastereoselectivity to provide aryl pyrroloindoline products in one step from simple starting materials. The utility of this transformation is highlighted in the five-step syntheses of the natural products (+)-naseseazine A and B.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 135 15 شماره
صفحات -
تاریخ انتشار 2013